Flow chemistry has become increasingly important in pharmaceutical development and manufacturing, representing a paradigm shift in chemical synthesis by offering a pathway to safer, more efficient, and environmentally responsible drug production. It enables:

• Rapid synthesis of drug candidates during discovery
• Efficient production of intermediates under tightly controlled conditions
• Continuous manufacturing of APIs with consistent quality
• Accelerated development timelines from lab to commercial scale
• Implementation of green chemistry principles, aligning with sustainable manufacturing goals

DASHA provides flow chemistry service solutions in line with GMP requirements. We also develop multiple platforms based on project requirements:

Core Equipment and Infrastructure

• Continuous flow reactors (typically microreactors, tubular reactors, and packed-bed reactors)
• High-pressure pumping systems capable of handling corrosive reagents
• Inline analytical monitoring (UV, IR, Raman spectroscopy, HPLC)
• Temperature control systems ranging from cryogenic to high-temperature conditions
• Back-pressure regulators for maintaining system pressure
• Automated control systems for process parameter monitoring and adjustment

Process Capabilities

• Hazardous chemistry handling (highly exothermic reactions, unstable intermediates)
• Photochemical transformations using flow photoreactors
• Electrochemical transformations in flow
• Heterogeneous catalysis in fixed-bed reactors
• Multiphase reactions (gas-liquid, liquid-liquid, solid-liquid)
• Continuous crystallization and precipitation
• Automated continuous liquid-liquid extraction

Scale Ranges

• Laboratory scale (typically 1-100 mL/min)
• Kilo-lab scale (100 mL – 1 L/min)
• Pilot scale (1-10 L/min)
• Manufacturing scale (>10 L/min, though this varies significantly by organization)

Technical Expertise

• Process development scientists trained in flow chemistry principles
• Process safety assessment for continuous operations
• Process analytical technology (PAT) implementation
• Scale-up methodology for transitioning batch to flow processes
• Regulatory documentation for flow processes

Regulatory and Quality Capabilities

• Validation protocols for continuous manufacturing
• Change control systems for process modifications
• Cleaning validation for continuous equipment
• Documentation for regulatory submissions
• Equipment qualification (IQ/OQ/PQ) for flow systems