DASHA offers specialised low-temperature capabilities essential for pharmaceutical and biopharmaceutical development and manufacturing. Our cryogenic manufacturing can be performed using continuous flow technology which offers improved temperature control, energy efficiency, and safety profiles for cryogenic reactions.

Storage and Handling

• Ultra-low freezers (-80°C) for long-term biological sample storage
• Liquid nitrogen systems (-196°C) for cell line and genetic material preservation
• Controlled rate freezers for optimized freezing protocols
• Temperature-mapped cold rooms (2-8°C) and freezers (-20°C)

Manufacturing Processes

• Cryogenic milling for processing temperature-sensitive compounds
• Low temperature chemical reactions (-78°C using dry ice/acetone baths)
• Freeze-drying/lyophilization for stability enhancement
• Cold filtration systems for temperature-sensitive solutions

Quality Control

• Temperature-controlled stability chambers
• Validated temperature monitoring systems with alarm capabilities
• Qualification and validation of all low temperature equipment
• Emergency power backup systems for critical storage

Logistics

• Temperature-controlled shipping solutions (2-8°C, -20°C, -80°C)
• Continuous temperature monitoring during transit
• Cold chain validation and qualification
• Contingency planning for temperature excursions